Guilherme Álvaro Ferreira‐Silva

Design, Synthesis, and Pharmacological Evaluation of Novel<i>N</i>-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors

Daniel Alencar Rodrigues, Guilherme Álvaro Ferreira‐Silva, Ana Carolina S. Ferreira et al. · Journal of Medicinal Chemistry · 2015 · 108 citations · Full text

Cellular Pharmacology, Pharmacotherapy, Pharmaceutical Chemistry +19

Design, synthesis and pharmacological evaluation of N -benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates

Flávia Pereira Dias Viegas, Matheus de Freitas Silva, Miguel Divino da Rocha et al. · European Journal of Medicinal Chemistry · 2018 · 62 citations · Full text

Combinatorial Chemistry, Alzheimer's Disease, Medicine +9

Synthetic resveratrol-curcumin hybrid derivative inhibits mitosis progression in estrogen positive MCF-7 breast cancer cells

Matheus de Freitas Silva, Letícia Ferreira Coelho, Isadora Mitestainer Guirelli et al. · Toxicology in Vitro · 2018 · 44 citations

Tumor Biology, Breast Oncology, Chemoprevention Strategy +10

Phenylpropanoid-based sulfonamide promotes cyclin D1 and cyclin E down-regulation and induces cell cycle arrest at G1/S transition in estrogen positive MCF-7 cell line

Helloana Azevedo‐Barbosa, Guilherme Álvaro Ferreira‐Silva, Carolina Faria Silva et al. · Toxicology in Vitro · 2019 · 36 citations

Signal Transduction, Cell Regulation, Cell Division +10

Alkaloids derived from flowers of Senna spectabilis, (−)-cassine and (−)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression

Rodrigo Machado Pereira, Guilherme Álvaro Ferreira‐Silva, Marcos Pivatto et al. · Toxicology in Vitro · 2015 · 31 citations · Full text

Signal Transduction, Chemoprevention Strategy, Biochemistry +11