Olaf H. Temmink

Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression

J. Sigmond, Harold H.J. Backus, Dorine Wouters et al. · Biochemical Pharmacology · 2003 · 147 citations · Full text

Medicine, Molecular Biology, Oncology +8

Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5‐fluorouracil in colon cancer cells

Irene V. Bijnsdorp, Godefridus J. Peters, Olaf H. Temmink et al. · International Journal of Cancer · 2009 · 93 citations

Life Sciences, Oncology, Pharmacology +17

Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells

Olaf H. Temmink, Eveline K. Hoebe, Kasper van der Born et al. · British Journal of Cancer · 2007 · 50 citations · Full text

Medicine, Oncology, Pharmacology +13

Irinotecan-induced cytotoxicity to colon cancer cells in vitro is stimulated by pre-incubation with trifluorothymidine

Olaf H. Temmink, Eveline K. Hoebe, Masakazu Fukushima et al. · European Journal of Cancer · 2006 · 35 citations

Medicine, Oncology, Pharmacology +10

Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines

Olaf H. Temmink, Michiel de Bruin, Annelies W. Turksma et al. · The International Journal of Biochemistry & Cell Biology · 2006 · 33 citations

Medicine, Molecular Biology, Oncology +15