J. Sigmond

Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression

J. Sigmond, Harold H.J. Backus, Dorine Wouters et al. · Biochemical Pharmacology · 2003 · 147 citations · Full text

Oncogenic Agent, Medicine, Thymidylate Synthase Overexpression +7

Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer

J. Sigmond, Richard J. Honeywell, Tjeerd J. Postma et al. · Annals of Oncology · 2008 · 89 citations · Full text

Neuro-oncology, Radiation Therapy, Glioma +5

Synthesis and Biological Activity of a Gemcitabine Phosphoramidate Prodrug

Weidong Wu, J. Sigmond, Godefridus J. Peters et al. · Journal of Medicinal Chemistry · 2007 · 52 citations · Full text

Cell-based Drug Delivery, Medicinal Chemistry, Pharmaceutical Science +13

Molecular pathways involved in the synergistic interaction of the PKCβ inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells

Christina Tekle, Elisa Giovannetti, J. Sigmond et al. · British Journal of Cancer · 2008 · 45 citations · Full text

The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent

J. Sigmond, J. A. E. Kamphuis, Adrianus C. Laan et al. · Biochemical Pharmacology · 2007 · 25 citations

Biochemistry, Natural Sciences, Protein Biosynthesis +7