Hans J. de Haard

A Large Non-immunized Human Fab Fragment Phage Library That Permits Rapid Isolation and Kinetic Analysis of High Affinity Antibodies

Hans J. de Haard, Nicole van Neer, Anneke W. Reurs et al. · Journal of Biological Chemistry · 1999 · 533 citations · Full text

Pharmacy, Biochemistry, Biotechnology +17

Efficient inhibition of EGFR signalling and of tumour growth by antagonistic anti-EGFR Nanobodies

Rob C. Roovers, Toon Laeremans, Lieven Huang et al. · Cancer Immunology Immunotherapy · 2006 · 344 citations · Full text

Medicine, Cancer Biology, Oncology +14

Improved tumor targeting of anti–epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology

Bernard M. Tijink, Toon Laeremans, Marianne Budde et al. · Molecular Cancer Therapeutics · 2008 · 294 citations

Pharmacy, Oncology, Pharmaceutics +17

CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

Sven Jähnichen, Christophe Blanchetot, David Maussang et al. · Proceedings of the National Academy of Sciences · 2010 · 249 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Llama-Derived Single Domain Antibodies to Build Multivalent, Superpotent and Broadened Neutralizing Anti-Viral Molecules

Anna Hultberg, Nigel Temperton, Valérie Rosseels et al. · PLoS ONE · 2011 · 195 citations · Full text

Pharmacy, Immunology, Infectious Diseases +17