Andrew D. Cansfield

A selective inhibitor reveals PI3Kγ dependence of TH17 cell differentiation

Giovanna Bergamini, Kathryn M. Bell, Satoko Shimamura et al. · Nature Chemical Biology · 2012 · 146 citations

Life Sciences, Biochemistry, Immunology +12

Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2

D.S. Williamson, Martin J. Parratt, Justin Bower et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 70 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: Protein structure-guided design and SAR

Christine M. Richardson, D.S. Williamson, Martin J. Parratt et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 69 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitors

Kathryn M. Bell, Mihiro Sunose, Katie Ellard et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 50 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7

Structure-Based Drug Discovery of <i>N</i> -(( <i>R</i> )-3-(7-Methyl-1 <i>H</i> -indazol-5-yl)-1-oxo-1-((( <i>S</i> )-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3- <i>d</i> ][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine

S.J. Bucknell, Mark A. Ator, Alastair Brown et al. · Journal of Medicinal Chemistry · 2020 · 18 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16