David McNair

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity

Richard L. Jarvest, John M. Berge, Murray J. B. Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 37 citations · Full text

Inhibitory Activity, Engineering, Medicine +10

ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Design and Synthesis of 2-Substituted Butanedioic Acids as Novel, Potent Inhibitors of the Enzyme

Andrew D. Gribble, Roland E. Dolle, Antony N. Shaw et al. · Journal of Medicinal Chemistry · 1996 · 33 citations · Full text

Hypolipidemic Intervention, Biosynthesis, Biochemistry +8

ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. 2. Synthesis and Evaluation of (3<i>R</i>*,5<i>S</i>*)-ω-Substituted-3-carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in Vitro and in Vivo

Andrew D. Gribble, Robert J. Ife, Antony N. Shaw et al. · Journal of Medicinal Chemistry · 1998 · 30 citations · Full text

Atp-citrate Lyase, Gamma-lactone Prodrugs, Pharmaceutical Chemistry +16

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-Positive antibacterial activity

Richard L. Jarvest, John M. Berge, Pamela Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 25 citations

Inhibitory Activity, Conformational Restriction, Biochemistry +11

Synthesis and Activity of Analogues of SB-219383. Novel Potent Inhibitors of Bacterial Tyrosyl tRNA Synthetase.

John M. Berge, N. J. P. BROOM, C. S. V. HOUGE‐FRYDRYCH et al. · The Journal of Antibiotics · 2000 · 22 citations · Full text