Dušana Majera

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

Zdeněk Škrott, Martin Mistrík, Klaus Kaae Andersen et al. · Nature · 2017 · 759 citations

Drug Target, Drug Targeting, Medicine +6

Disulfiram’s anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase

Zdeněk Škrott, Dušana Majera, Ján Gurský et al. · Oncogene · 2019 · 114 citations

Medicinal Chemistry, Aldehyde Dehydrogenase, Biochemistry +9

Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft

M. Renko, Urška Požgan, Dušana Majera · FEBS Journal · 2010 · 61 citations

Protein Chemistry, Active Site Cleft, Crystal Structure +14

DNA damage signalling barrier, oxidative stress and treatment‐relevant DNA repair factor alterations during progression of human prostate cancer

Daniela Kurfürstová, Jiřina Bártková, Radek Vrtěl et al. · Molecular Oncology · 2016 · 51 citations · Full text

Dna Damage, Molecular Biology, Cancer Biology +19

PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair

M Vancurová, Hana Hanzlíková, Lucie Knoblochová et al. · DNA repair · 2019 · 46 citations

Chromatin, Genome Instability, Dna Damage +9