Zdeněk Škrott

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

Zdeněk Škrott, Martin Mistrík, Klaus Kaae Andersen et al. · Nature · 2017 · 759 citations

Drug Target, Drug Targeting, Medicine +6

Disulfiram’s anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase

Zdeněk Škrott, Dušana Majera, Ján Gurský et al. · Oncogene · 2019 · 114 citations

Medicinal Chemistry, Aldehyde Dehydrogenase, Biochemistry +9

Diethyldithiocarbamate complex with copper: the mechanism of action in cancer cells

Zdeněk Škrott, Boris Cvek · Mini-Reviews in Medicinal Chemistry · 2012 · 85 citations

Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress

Katarína Chromá, Martin Mistrík, Pavel Moudrý et al. · Oncogene · 2016 · 53 citations

Genome Instability, Rnf168 Show, Dna Damage +8

Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway

Dušana Majera, Zdeněk Škrott, Katarína Chromá et al. · Cells · 2020 · 43 citations · Full text

Genome Instability, Chemoprevention Strategy, Natural Sciences +15