Naim Nazef

A General Technique To Rank Protein−Ligand Binding Affinities and Determine Allosteric versus Direct Binding Site Competition in Compound Mixtures

D. Allen Annis, Naim Nazef, Cheng‐Chi Chuang et al. · Journal of the American Chemical Society · 2004 · 130 citations

Drug Target, Hit Identification, Compound Mixtures +19

Specific Inhibition of Hepatic Lactate Dehydrogenase Reduces Oxalate Production in Mouse Models of Primary Hyperoxaluria

Cheng-Jung Lai, Natalie W. Pursell, Jessica J. Gierut et al. · Molecular Therapy · 2018 · 104 citations · Full text

Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1

Chaitali Dutta, Nicole Avitahl-Curtis, Natalie W. Pursell et al. · Molecular Therapy · 2016 · 82 citations · Full text

Discovery of a 5<i>H</i>-Benzo[4,5]cyclohepta[1,2-<i>b</i>]pyridin-5-one (MK-2461) Inhibitor of c-Met Kinase for the Treatment of Cancer

Jason D. Katz, James P. Jewell, David Guérin et al. · Journal of Medicinal Chemistry · 2011 · 60 citations · Full text

Tumor Biology, Aberrant C-met Signaling, Drug Target +14

Discovery and Characterization of Orthosteric and Allosteric Muscarinic M2 Acetylcholine Receptor Ligands by Affinity Selection–Mass Spectrometry

Charles E. Whitehurst, Naim Nazef, D. Allen Annis et al. · SLAS DISCOVERY · 2006 · 49 citations · Full text

Drug Target, Biological Mass Spectrometry, Small-molecule Ligands +19