Alexander W. Hird

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

Adriana E. Tron, Matthew A. Belmonte, Ammar Adam et al. · Nature Communications · 2018 · 486 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

A Practical Method for Enantioselective Synthesis of All-Carbon Quaternary Stereogenic Centers through NHC-Cu-Catalyzed Conjugate Additions of Alkyl- and Arylzinc Reagents to β-Substituted Cyclic Enones

Kang-Sang Lee, M. Kevin Brown, Alexander W. Hird et al. · Journal of the American Chemical Society · 2006 · 233 citations

Natural Sciences, Chemistry, Catalysis +10

Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain

Gizem Akçay, Matthew A. Belmonte, Brian Aquila et al. · Nature Chemical Biology · 2016 · 194 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Small peptides as ligands for catalytic asymmetric alkylations of olefins. Rational design of catalysts or of searches that lead to them?

Amir H. Hoveyda, Alexander W. Hird, Monica A. Kacprzynski · Chemical Communications · 2004 · 162 citations

Natural Sciences, Chemistry, Biocatalysis +15

Catalytic Enantioselective Alkylations of Tetrasubstituted Olefins. Synthesis of All-Carbon Quaternary Stereogenic Centers through Cu-Catalyzed Asymmetric Conjugate Additions of Alkylzinc Reagents to Enones

Alexander W. Hird, Amir H. Hoveyda · Journal of the American Chemical Society · 2005 · 148 citations

Natural Sciences, Chemistry, Catalysis +14