Ross Strang

Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors

Klemens Hoegenauer, Nicolas Soldermann, Frédéric J. Zécri et al. · ACS Medicinal Chemistry Letters · 2017 · 118 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

Stéphane Ferretti, Jacques Hamon, Ruben de Kanter et al. · Nature · 2024 · 113 citations · Full text

Life Sciences, Oncology, Pharmacology +17

Inhalation by Design: Novel Tertiary Amine Muscarinic M₃Receptor Antagonists with Slow Off-Rate Binding Kinetics for Inhaled Once-Daily Treatment of Chronic Obstructive Pulmonary Disease

Paul A. Glossop, Christine Watson, David Price et al. · Journal of Medicinal Chemistry · 2011 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Challenges for the Discovery of Non‐Covalent WRN Helicase Inhibitors

Alisa Heuser, Wassim Abdul Rahman, Elisabeth Bechter et al. · ChemMedChem · 2024 · 24 citations

Life Sciences, Biochemistry, Molecular Biology +15

Structure-Based and Property-Driven Optimization of <i>N</i>-Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors

Klemens Hoegenauer, Joerg Kallen, Eloísa Jiménez‐Núñez et al. · Journal of Medicinal Chemistry · 2019 · 20 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15