Aaron A. Koch

Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C—H Functionalization

Andrew N. Lowell, Matthew D. DeMars, Samuel T. Slocum et al. · Journal of the American Chemical Society · 2017 · 90 citations · Full text

Bioorganic Chemistry, Engineering, Terminal Pks Modules +21

A Single Active Site Mutation in the Pikromycin Thioesterase Generates a More Effective Macrocyclization Catalyst

Aaron A. Koch, Douglas A. Hansen, Vikram V. Shende et al. · Journal of the American Chemical Society · 2017 · 60 citations · Full text

Identification of a Thioesterase Bottleneck in the Pikromycin Pathway through Full-Module Processing of Unnatural Pentaketides

Douglas A. Hansen, Aaron A. Koch, David H. Sherman · Journal of the American Chemical Society · 2017 · 42 citations · Full text

Substrate Controlled Divergence in Polyketide Synthase Catalysis

Douglas A. Hansen, Aaron A. Koch, David H. Sherman · Journal of the American Chemical Society · 2015 · 33 citations · Full text

Biosynthesis, Polyketide Synthase Catalysis, Engineering +15

Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases

Aaron A. Koch, Jennifer J. Schmidt, Andrew N. Lowell et al. · Angewandte Chemie International Edition · 2020 · 19 citations · Full text