Andrew N. Lowell

Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C—H Functionalization

Andrew N. Lowell, Matthew D. DeMars, Samuel T. Slocum et al. · Journal of the American Chemical Society · 2017 · 93 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17

Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C–C Bond-Forming Cascade

Shasha Li, Andrew N. Lowell, Fengan Yu et al. · Journal of the American Chemical Society · 2015 · 78 citations

Pharmacy, Chemistry, Molecular Biology +12

Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering

Irina Koryakina, Christian Kasey, John B. McArthur et al. · ACS Chemical Biology · 2016 · 68 citations · Full text

Life Sciences, Biochemistry, Biotechnology +17

Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units

Edward Kalkreuter, Jared Matthew CroweTipton, Andrew N. Lowell et al. · Journal of the American Chemical Society · 2019 · 54 citations

Engineering, Biotechnology, Molecular Biology +16

A Concise Synthesis of the Naphthalene Portion of Purpuromycin

Andrew N. Lowell, Michael W. Fennie, Marisa C. Kozlowski · The Journal of Organic Chemistry · 2008 · 52 citations

Pharmacy, Chemistry, Medicinal Chemistry +15