Spiroindolone KAE609 for Falciparum and Vivax Malaria

Nicholas J. White, Sasithon Pukrittayakamee, Aung Pyae Phyo, +10

New England Journal of Medicine

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis

Ujjini H. Manjunatha, Sumiti Vinayak, Jennifer A. Zambriski, +23

Nature

PharmacologyMedicinePathologyCryptosporidium Pi

Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria

Nicholas J. White, Tran Thanh Duong, Chirapong Uthaisin, +17

New England Journal of Medicine

A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Antimalarial Spiroindolone KAE609 (Cipargamin) To Assess Its Safety, Tolerability, and Pharmacokinetics in Healthy Adult Volunteers

F. Joel Leong, Ruobing Li, Jay Prakash Jain, +4

Antimicrobial Agents and Chemotherapy

Drug SafetyHealthy Adult VolunteersPharmacological StudyAntiparasitic AgentMalaria +12

A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Imidazolopiperazine KAF156 To Assess Its Safety, Tolerability, and Pharmacokinetics in Healthy Adult Volunteers

F. Joel Leong, Rong Zhao, Shuqi Zeng, +3

Antimicrobial Agents and Chemotherapy

Antiparasitic AgentAbstract Kaf156MalariaPharmacotherapyPre-clinical Pharmacology +16

Bioavailability of Lumefantrine Is Significantly Enhanced with a Novel Formulation Approach, an Outcome from a Randomized, Open-Label Pharmacokinetic Study in Healthy Volunteers

Jay Prakash Jain, F. Joel Leong, Lan Chen, +6

Antimicrobial Agents and Chemotherapy

Drug SafetySdf Variant 2Therapeutic Drug MonitoringNovel Formulation ApproachPharmacokinetic Modeling +13

Drug resistance among tuberculosis patients attending diagnostic and treatment centres in Makassar, Indonesia

Muhammad Nasrum Massi, Sitti Wahyuni, Handayani Halik, +5

The International Journal of Tuberculosis and Lung Disease

Safety, Pharmacokinetics, and Causal Prophylactic Efficacy of KAF156 in a <i>Plasmodium falciparum</i> Human Infection Study

James G. Kublin, Sean C. Murphy, Janine Maenza, +15

Clinical Infectious Diseases

A phase 1 evaluation of the pharmacokinetic/pharmacodynamic interaction of the anti-malarial agents KAF156 and piperaquine

F. Joel Leong, Jay Prakash Jain, Yiyan Feng, +2

Malaria Journal

Mutation-Attention (MuAt): deep representation learning of somatic mutations for tumour typing and subtyping

Prima Sanjaya, Katri Maljanen, Riku Katainen, +65

Genome Medicine