Gerjan de Bruin

Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation

Emily S. Weyburne, Owen M. Wilkins, Zhe Sha et al. · Cell chemical biology · 2017 · 113 citations · Full text

Breast Oncology, Medicine, Cancer Cell Biology +9

Proteasome Inhibition in Multiple Myeloma: Head-to-Head Comparison of Currently Available Proteasome Inhibitors

Andrej Bešše, Lenka Bešše, Marianne Kraus et al. · Cell chemical biology · 2019 · 112 citations · Full text

Hematological Malignancy, Proteasome Inhibition, Oncology +11

A Set of Activity‐Based Probes to Visualize Human (Immuno)proteasome Activities

Gerjan de Bruin, B. Xin, Marianne Kraus et al. · Angewandte Chemie International Edition · 2015 · 103 citations

Proteasome Inhibitors, Immunology, Proteasome +16

Structure-Based Design of β1i or β5i Specific Inhibitors of Human Immunoproteasomes

Gerjan de Bruin, E.M. Huber, Bo‐Tao Xin et al. · Journal of Medicinal Chemistry · 2014 · 97 citations · Full text

Proteasome Inhibitors, Drug Target, Human Immunoproteasomes +23

Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites

Paul P. Geurink, Wouter A. van der Linden, Anne Mirabella et al. · Journal of Medicinal Chemistry · 2013 · 94 citations · Full text

Active Sites, Chemical Biology, Medicinal Chemistry +16