PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses

Jiqing Sai, Philip Owens, Sergey V. Novitskiy, +14

Clinical Cancer Research

Targeting aurora kinases limits tumour growth through DNA damage‐mediated senescence and blockade of NF‐κB impairs this drug‐induced senescence

Yan Liu, Oriana E. Hawkins, Yingjun Su, +11

EMBO Molecular Medicine

CXCR4 drives the metastatic phenotype in breast cancer through induction of CXCR2 and activation of MEK and PI3K pathways

Tammy Sobolik, Yingjun Su, Sam Wells, +3

Molecular Biology of the Cell

Breast OncologyCancer BiologyTumor BiologySignaling PathwayCell Regulation +14

RAF265 Inhibits the Growth of Advanced Human Melanoma Tumors

Yingjun Su, Anna E. Vilgelm, Mark C. Kelley, +16

Clinical Cancer Research

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

Timothy R. Hodges, Jason R. Abbott, Andrew J. Little, +19

Journal of Medicinal Chemistry

Combinatorial ChemistryGtp-bound RasMolecular BiologyStructure-based OptimizationNew Series +25

mTOR Directs Breast Morphogenesis through the PKC-alpha-Rac1 Signaling Axis

Meghan M. Morrison, Christian D. Young, Shan Wang, +5

PLoS Genetics

Signal TransductionSignaling PathwayCell RegulationMedicineReceptor Tyrosine Kinase +12

Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling

Jason R. Abbott, Timothy R. Hodges, R. Nathan Daniels, +13

Journal of Medicinal Chemistry

Engineered microfluidic bioreactor for examining the three-dimensional breast tumor microenvironment

Matthew E. Rogers, Tammy Sobolik, David K. Schaffer, +8

Biomicrofluidics

Tissue EngineeringEngineeringBiological MicroenvironmentsBiofabricationOrgan-on-a-chip +19

Development of novel murine mammary imaging windows to examine wound healing effects on leukocyte trafficking in mammary tumors with intravital imaging

Tammy Sobolik, Yingjun Su, Will Ashby, +5

IntraVital