Henry A. Kelly

Factor Xa Inhibitors:  S1 Binding Interactions of a Series of <i>N</i>-{(<i>3S</i>)-1-[(<i>1S</i>)-1-Methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides

Chuen Chan, Alan D. Borthwick, David Brown et al. · Journal of Medicinal Chemistry · 2007 · 49 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure- and property-based design of factor Xa inhibitors: Pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs

Robert J. Young, Matthew Campbell, Alan D. Borthwick et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors

Nigel S. Watson, David Brown, Matthew Campbell et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 30 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with biaryl P4 motifs

Robert J. Young, Alan D. Borthwick, David Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 29 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Structure and property based design of factor Xa inhibitors: Biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs

Robert J. Young, Alan D. Borthwick, David Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16