PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade

Peng Qi, Xiangyan Qiu, Zihan Zhang, +8

Nature Communications

PD-L1 on host cells is essential for PD-L1 blockade–mediated tumor regression

Haidong Tang, Yong Liang, Robert A. Anders, +18

Journal of Clinical Investigation

DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity

Changzheng Lu, Junhong Guan, Steve Lu, +23

Cancer Cell

Genome InstabilityCancer ImmunosurveillanceImmunologyTumor ImmunityDna Replication +7

A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control

Zhichen Sun, Zhenhua Ren, Kaiting Yang, +12

Nature Communications

High-fidelity structured illumination microscopy by point-spread-function engineering

Gang Wen, Simin Li, Linbo Wang, +8

Light Science & Applications

Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota

Xiaohuan Guo, Yong Liang, Yuan Zhang, +3

Immunity

Intestinal PathogensDysbiosisMucosal ImmunologyPathogenesisImmunology +9

Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia

Han Dong, James Dongjoo Ham, Guangan Hu, +14

Proceedings of the National Academy of Sciences

The Chinese rare minnow (Gobiocypris rarus) as an in vivo model for endocrine disruption in freshwater teleosts: a full life-cycle test with diethylstilbestrol

Xueping Zhong, Ying Xu, Yong Liang, +2

Aquatic Toxicology

BiologyAquatic Food SystemFreshwater TeleostsVivo ModelFish Immunology +2

Androgen receptor antagonists compromise T cell response against prostate cancer leading to early tumor relapse

Yang Pu, Meng Xu, Yong Liang, +4

Science Translational Medicine

Next generation of tumor-activating type I IFN enhances anti-tumor immune responses to overcome therapy resistance

Xuezhi Cao, Yong Liang, Zhenxiang Hu, +6

Nature Communications