Ilse Biesmans

Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor

Gary Tresadern, José M. Cid, Gregor J. Macdonald et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 73 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Pharmacological Characterization of JNJ-40068782, a New Potent, Selective, and Systemically Active Positive Allosteric Modulator of the mGlu2 Receptor and Its Radioligand [3H]JNJ-40068782

Hilde Lavreysen, Xavier Langlois, Wilhelmus Drinkenburg et al. · Journal of Pharmacology and Experimental Therapeutics · 2013 · 63 citations

Medicine, Neuroscience, Pharmacology +16

Discovery of a New Series of Centrally Active Tricyclic Isoxazoles Combining Serotonin (5-HT) Reuptake Inhibition with α₂-Adrenoceptor Blocking Activity

José Ignacio Andrés, Jesús Alcázar, José Manuel Alonso Segura et al. · Journal of Medicinal Chemistry · 2004 · 50 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Synthesis and Biological Activities of Conformationally Restricted Cyclopentenyl-Glutamate Analogues

Alison T. Ung, Karl Schafer, Karl B. Lindsay et al. · The Journal of Organic Chemistry · 2001 · 47 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ‐46281222

Maarten L. J. Doornbos, Laura Pérez‐Benito, Gary Tresadern et al. · British Journal of Pharmacology · 2015 · 45 citations · Full text

Medicine, Neuroscience, Pharmacology +17