Joy E. Horng

Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

Benjamin P. Kleinstiver, Alexander A. Sousa, Russell T. Walton et al. · Nature Biotechnology · 2019 · 690 citations

Base Editing, Engineered Crispr–cas12a Variants, Engineering +12

Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10

Morgan L. Maeder, Michael Stefanidakis, Christopher J. Wilson et al. · Nature Medicine · 2019 · 674 citations

Ocular Disease, Developmental Biology, Retina +9

Inducible and multiplex gene regulation using CRISPR–Cpf1-based transcription factors

Y. Esther Tak, Benjamin P. Kleinstiver, James K. Nuñez et al. · Nature Methods · 2017 · 209 citations · Full text

CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells

Karl Petri, Weiting Zhang, Junyan Ma et al. · Nature Biotechnology · 2021 · 205 citations · Full text

Off-target Effect, Ribonucleoprotein Complexes, Genetics +8

Global-scale CRISPR gene editor specificity profiling by ONE-seq identifies population-specific, variant off-target effects

Karl Petri, Daniel Y. Kim, Kanae Sasaki et al. · 2021 · 39 citations · Full text

Engineering, In Vivo Gene Therapy, Genetics +21