Concepedia

Patricia Kruchten

PK

Statistics

Publications

13

Citations

680

H-Index

12

Active since

2006

Affiliations

Saarland University(Current)

Solvay (Germany)

Helmholtz Institute for Pharmaceutical Research Saarland

Patricia Kruchten is an author at Saarland University specializing in pharmacology, 17-beta hydroxysteroid dehydrogenase, and medicinal chemistry.

Publications per year

2006–2010

13

Publications

13

Design, Synthesis, Biological Evaluation and Pharmacokinetics of Bis(hydroxyphenyl) substituted Azoles, Thiophenes, Benzenes, and Aza-Benzenes as Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)

Emmanuel Bey, Sandrine Marchais‐Oberwinkler, Ruth Werth et al. · Journal of Medicinal Chemistry · 2008 · 107 citations · Full text

, , +17

Design, Synthesis, and Biological Evaluation of (Hydroxyphenyl)naphthalene and -quinoline Derivatives: Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) for the Treatment of Estrogen-Dependent Diseases

Martin Frotscher, Erika Ziegler, Sandrine Marchais‐Oberwinkler et al. · Journal of Medicinal Chemistry · 2008 · 87 citations · Full text

, , +17

New Insights into the SAR and Binding Modes of Bis(hydroxyphenyl)thiophenes and -benzenes: Influence of Additional Substituents on 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitory Activity and Selectivity

Emmanuel Bey, Sandrine Marchais‐Oberwinkler, Matthias Negri et al. · Journal of Medicinal Chemistry · 2009 · 76 citations · Full text

, , +16

Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases

Emmanuel Bey, Sandrine Marchais‐Oberwinkler, Patricia Kruchten et al. · Bioorganic & Medicinal Chemistry · 2008 · 65 citations · Full text

, , +17

Substituted 6-Phenyl-2-naphthols. Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Design, Synthesis, Biological Evaluation, and Pharmacokinetics

Sandrine Marchais‐Oberwinkler, Patricia Kruchten, Martin Frotscher et al. · Journal of Medicinal Chemistry · 2008 · 63 citations · Full text

, , +17

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