Kirsten M. Knecht

SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways

Shuliang Chen, Serena Bonifati, Zhihua Qin et al. · Proceedings of the National Academy of Sciences · 2018 · 122 citations

Life Sciences, Immunology, Infectious Diseases +17

Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML

Thomas Oellerich, Constanze Schneider, Dominique Thomas et al. · Nature Communications · 2019 · 84 citations · Full text

Medicine, Oncology, Pharmacology +15

The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1

Kirsten M. Knecht, Olga Buzovetsky, Constanze Schneider et al. · Proceedings of the National Academy of Sciences · 2018 · 62 citations · Full text

Medicine, Oncology, Pharmacology +15

A bacterial riboswitch class for the thiamin precursor HMP-PP employs a terminator-embedded aptamer

Ruben M. Atilho, Gayan Mirihana Arachchilage, Etienne B. Greenlee et al. · eLife · 2019 · 38 citations · Full text

Life Sciences, Microbiology, Molecular Biology +16

SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4 ⁺ T Cells

Jenna M. Antonucci, Sun‐Hee Kim, Corine St. Gelais et al. · Journal of Virology · 2018 · 34 citations · Full text

Life Sciences, Immunology, Molecular Biology +13