Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

Vicky Lampropoulou, Alexey Sergushichev, Monika Bambousková, +15

Cell Metabolism

InflammationSuccinate DehydrogenaseMacrophage Metabolic RemodelingAnti-inflammatoryItaconate Links Inhibition +10

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

Emma S. Winkler, Adam L. Bailey, Natasha M. Kafai, +14

Nature Immunology

Inflammatory Lung DiseaseLung InflammationSars-cov-2 InfectionViral PathogenesisImmunology +6

Mxra8 is a receptor for multiple arthritogenic alphaviruses

Rong Zhang, Arthur S. Kim, Julie M. Fox, +11

Nature

Molecular VirologyAutoimmune DiseaseImmunologyVirologyMedicine +3

<i>Irg1</i> expression in myeloid cells prevents immunopathology during <i>M. tuberculosis</i> infection

Sharmila Nair, Jeremy Huynh, Vicky Lampropoulou, +10

The Journal of Experimental Medicine

Type I Interferon Protects Mice from Fatal Neurotropic Infection with Langat Virus by Systemic and Local Antiviral Responses

Elvira Weber, Katja Finsterbusch, R R Lindquist, +7

Journal of Virology

Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade

Sharmila Nair, Luciano Mazzoccoli, Arijita Jash, +11

JCI Insight

Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1

Chaitanya Kurhade, Loreen Zegenhagen, Elvira Weber, +6

Journal of Neuroinflammation

Interferon Regulatory Factor 1 Protects against Chikungunya Virus-Induced Immunopathology by Restricting Infection in Muscle Cells

Sharmila Nair, Subhajit Poddar, Raeann M. Shimak, +1

Journal of Virology

SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function

Emma S. Winkler, Adam L. Bailey, Natasha M. Kafai, +14

Interferon Regulatory Factor-1 Protects from Fatal Neurotropic Infection with Vesicular Stomatitis Virus by Specific Inhibition of Viral Replication in Neurons

Sharmila Nair, Kristin Michaelsen‐Preusse, Katja Finsterbusch, +8

PLoS Pathogens