Benjamin L. Zaepfel

G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD

Alyssa N. Coyne, Benjamin L. Zaepfel, Lindsey R. Hayes et al. · Neuron · 2020 · 155 citations · Full text

G4c2 Repeat Rna, Chromatin, Transcriptional Regulation +12

Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS

Alyssa N. Coyne, Victoria Baskerville, Benjamin L. Zaepfel et al. · Science Translational Medicine · 2021 · 134 citations · Full text

Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export

Lauren Duan, Benjamin L. Zaepfel, Vasilisa Aksenova et al. · Cell Reports · 2022 · 101 citations · Full text

Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation

Alyssa N. Coyne, Shizuka Yamada, Bhavani B. Siddegowda et al. · Human Molecular Genetics · 2015 · 95 citations · Full text

Genetics, Molecular Biology, Tdp-43 Toxicity +17

UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction

Benjamin L. Zaepfel, Zhe Zhang, Kirstin Maulding et al. · Cell Reports · 2021 · 29 citations · Full text