Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

Bahareh Eftekharzadeh, J. Gavin Daigle, Larisa E. Kapinos, +27

Neuron

Neurodegenerative DiseasesAlzheimer's DiseaseMolecular NeuroscienceMedicineMolecular Biology +6

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

Ke Zhang, J. Gavin Daigle, Kathleen M. Cunningham, +11

Cell

ChromatinNatural SciencesMolecular BiologyNuclear OrganizationCytoskeleton +6

G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD

Alyssa N. Coyne, Benjamin L. Zaepfel, Lindsey R. Hayes, +12

Neuron

G4c2 Repeat RnaChromatinTranscriptional RegulationSystems BiologyNucleic Acid Chemistry +10

Futsch/MAP1B mRNA Is a Translational Target of TDP-43 and Is Neuroprotective in a<i>Drosophila</i>Model of Amyotrophic Lateral Sclerosis

Alyssa N. Coyne, Bhavani B. Siddegowda, Patricia S. Estes, +6

Journal of Neuroscience

Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines

Emily G. Baxi, Terri G. Thompson, Jonathan Li, +97

Nature Neuroscience

CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation

Weiwei Cheng, Shaopeng Wang, Zhe Zhang, +19

Neuron

Rna ProcessingNatural SciencesGeneticsRna Helicase Ddx3xMolecular Biology +8

Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS

Alyssa N. Coyne, Victoria Baskerville, Benjamin L. Zaepfel, +5

Science Translational Medicine

Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model

Lien Nguyen, Fabio Montrasio, Amrutha Pattamatta, +19

Neuron

Neurodegenerative DiseasesAmyotrophic Lateral SclerosisAutoimmune DiseaseImmunologyAntibody Engineering +3

Endocytosis regulates TDP-43 toxicity and turnover

Guangbo Liu, Alyssa N. Coyne, Fen Pei, +4

Nature Communications

Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation

Alyssa N. Coyne, Shizuka Yamada, Bhavani B. Siddegowda, +13

Human Molecular Genetics

GeneticsMolecular BiologyTdp-43 ToxicityDegenerative PathologyRna Processing +15