R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease

Eiko Hayase, Daigo Hashimoto, Kiminori Nakamura, +21

The Journal of Experimental Medicine

Chronic Inflammatory DiseasesDysbiosisMicrobial PathogensHost-microbe InteractionsImmunology +26

Essential role of IFN-γ in T cell–associated intestinal inflammation

Yoshihiro Eriguchi, Kiminori Nakamura, Yuki Yokoi, +7

JCI Insight

Gastrointestinal PharmacologyImmune RegulationImmunologyPaneth CellImmunologic Mechanism +17

Butyric Acid and Leucine Induce α-Defensin Secretion from Small Intestinal Paneth Cells

Akiko Takakuwa, Kiminori Nakamura, Mani Kikuchi, +4

Nutrients

Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids

Yuki Yokoi, Kiminori Nakamura, Tsukasa Yoneda, +4

Scientific Reports

Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model

Kosuke Suzuki, Kiminori Nakamura, Yu Shimizu, +7

Scientific Reports

Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model mice

Yu Shimizu, Kiminori Nakamura, Aki Yoshii, +7

Life Science Alliance

Shorter sleep time relates to lower human defensin 5 secretion and compositional disturbance of the intestinal microbiota accompanied by decreased short-chain fatty acid production

Yu Shimizu, Ryodai Yamamura, Yuki Yokoi, +3

Gut Microbes

Expression and Localization of Paneth Cells and Their α-Defensins in the Small Intestine of Adult Mouse

Kiminori Nakamura, Yuki Yokoi, Rie Fukaya, +5

Frontiers in Immunology

Mycotoxin Deoxynivalenol Has Different Impacts on Intestinal Barrier and Stem Cells by Its Route of Exposure

Hikaru Hanyu, Yuki Yokoi, Kiminori Nakamura, +9

Toxins

Decreased Paneth cell α-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiota

Shunta Nakamura, Kiminori Nakamura, Yuki Yokoi, +10

Scientific Reports