John C. Murray

IN VITRO METABOLISM STUDIES ON THE ISOXAZOLE RING SCISSION IN THE ANTI-INFLAMMATORY AGENT LEFLUNOMIDE TO ITS ACTIVE α-CYANOENOL METABOLITE A771726: MECHANISTIC SIMILARITIES WITH THE CYTOCHROME P450-CATALYZED DEHYDRATION OF ALDOXIMES

Amit S. Kalgutkar, Nguyen Thi Thu Hang, Alfin D. N. Vaz et al. · Drug Metabolism and Disposition · 2003 · 114 citations

<i>In Vitro</i> and <i>In Vivo</i> Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection

Thomas Colley, Alexandre Alanio, Steven L. Kelly et al. · Antimicrobial Agents and Chemotherapy · 2017 · 82 citations · Full text

Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

Michael A. Brodney, Elizabeth M. Beck, Christopher R. Butler et al. · Journal of Medicinal Chemistry · 2015 · 78 citations · Full text

Reduce Risk, Drug Target, Peptide Science +21

Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent

Lindsey Cass, Alison D. Murray, Amanda Davis et al. · Pharmacology Research & Perspectives · 2020 · 63 citations · Full text

Spirocyclic Sulfamides as β-Secretase 1 (BACE-1) Inhibitors for the Treatment of Alzheimer’s Disease: Utilization of Structure Based Drug Design, WaterMap, and CNS Penetration Studies To Identify Centrally Efficacious Inhibitors

Michael A. Brodney, Gabriela Barreiro, Kevin Ogilvie et al. · Journal of Medicinal Chemistry · 2012 · 60 citations · Full text

Drug Target, Peptide Science, Pharmacotherapy +20