A novel multiple-stage antimalarial agent that inhibits protein synthesis

Beatriz Baragaña, Irene Hallyburton, Neil R. Norcross, +60

Nature

Antiparasitic AgentMedicineMalariaPharmacologyProtein Synthesis +2

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

Julie A. Frearson, Stephen Brand, Stuart P. McElroy, +23

Nature

SleepSleep DisorderN-myristoyltransferase InhibitorsPharmacologyPharmacotherapy +3

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

Manu De Rycker, Irene Hallyburton, John Thomas, +9

Antimicrobial Agents and Chemotherapy

Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials

Edwin G. Tse, Sevan D. Houston, Craig M. Williams, +8

Journal of Medicinal Chemistry

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Beatriz Baragaña, Barbara Forte, Ryan Choi, +74

Proceedings of the National Academy of Sciences

Induction of diverse secondary metabolites in Aspergillus fumigatus by microbial co-culture

Mostafa E. Rateb, Irene Hallyburton, Wael E. Houssen, +5

RSC Advances

Industrial MycologySecondary MetabolismBiosynthesisAntifungal AgentBiochemistry +12

Discovery of a Novel Class of Orally Active Trypanocidal <i>N</i>-Myristoyltransferase Inhibitors

Stephen Brand, Laura A. T. Cleghorn, Stuart P. McElroy, +17

Journal of Medicinal Chemistry

Whole Organism High-Content Screening by Label-Free, Image-Based Bayesian Classification for Parasitic Diseases

Ross A. Paveley, Nuha R. Mansour, Irene Hallyburton, +7

PLoS neglected tropical diseases

Parasitic DiseaseEngineeringHit IdentificationMalariaDiagnosis +24

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles

Alice Williamson, Paul M. Ylioja, Murray N. Robertson, +50

ACS Central Science

Antiparasitic AgentMalariaTres Cantos ArylpyrrolesPharmaceutical ChemistryMedicinal Chemistry +14

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

Beatriz Baragaña, Neil R. Norcross, Caroline Wilson, +24

Journal of Medicinal Chemistry