pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation

Lutz Nuhn, Nane Vanparijs, Ans De Beuckelaer, +11

Proceedings of the National Academy of Sciences

Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure–Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds

Euna Yoo, Deepak B. Salunke, Diptesh Sil, +11

Journal of Medicinal Chemistry

Drug TargetImmunologyToll-like ReceptorMolecular BiologyDiverse Heterocyclic Scaffolds +16

Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity

Mallesh Beesu, Giuseppe Caruso, Alex C. D. Salyer, +7

Journal of Medicinal Chemistry

Innate Immune SystemImmunologyImmune RegulationPharmacotherapyImmunotherapeutics +25

Synthesis and Immunological Evaluation of a MUC1 Glycopeptide Incorporated into <scp>l</scp>-Rhamnose Displaying Liposomes

Sourav Sarkar, Alex C. D. Salyer, Katherine A. Wall, +1

Bioconjugate Chemistry

Tlrl-muc1-tn ConjugateGlycobiologyImmunologyImmunotherapeuticsImmunotherapy +15

Identification of Adjuvantic Activity of Amphotericin B in a Novel, Multiplexed, Poly-TLR/NLR High-Throughput Screen

Alex C. D. Salyer, Giuseppe Caruso, Karishma K. Khetani, +3

PLoS ONE

Pharmaceutical ScienceDrug TargetAntibiotic AdjuvantInnate Immune SystemImmunology +23

Identification of a Human Toll-Like Receptor (TLR) 8-Specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles

Mallesh Beesu, Giuseppe Caruso, Alex C. D. Salyer, +8

Journal of Medicinal Chemistry

Human Toll-like ReceptorCrystal StructureInnate Immune SystemImmunologyPharmacotherapy +14

Identification of High-Potency Human TLR8 and Dual TLR7/TLR8 Agonists in Pyrimidine-2,4-diamines

Mallesh Beesu, Alex C. D. Salyer, Michael J. H. Brush, +3

Journal of Medicinal Chemistry

Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue

Euna Yoo, Alex C. D. Salyer, Michael J. H. Brush, +9

Bioconjugate Chemistry

EngineeringTlr7/8 AgonistsTargeted DeliveryImmunologyAntigen Processing +17

Human Toll-like Receptor (TLR) 8-Specific Agonistic Activity in Substituted Pyrimidine-2,4-diamines

Mallesh Beesu, Alex C. D. Salyer, Kathryn L. Trautman, +2

Journal of Medicinal Chemistry

Identification of Human Toll-like Receptor 2-Agonistic Activity in Dihydropyridine–Quinolone Carboxamides

Ziwei Hu, Janardhan Banothu, Mallesh Beesu, +6

ACS Medicinal Chemistry Letters