Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure–Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds

Euna Yoo, Deepak B. Salunke, Diptesh Sil, +11

Journal of Medicinal Chemistry

Drug TargetImmunologyToll-like ReceptorMolecular BiologyDiverse Heterocyclic Scaffolds +16

Exquisite Selectivity for Human Toll-Like Receptor 8 in Substituted Furo[2,3-<i>c</i>]quinolines

Hari Prasad Kokatla, Diptesh Sil, Subbalakshmi S. Malladi, +6

Journal of Medicinal Chemistry

Tlr8-active CompoundsInnate Immune SystemImmunologyToll-like ReceptorExquisite Selectivity +19

Toll-like receptor-8 agonistic activities in C2, C4, and C8 modified thiazolo[4,5-c]quinolines

Hari Prasad Kokatla, Euna Yoo, Deepak B. Salunke, +6

Organic & Biomolecular Chemistry

Tlr8-active CompoundsToll-like ReceptorsMedicinal ChemistryAllergyTlr8 Agonistic Activity +11

Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity

Mallesh Beesu, Giuseppe Caruso, Alex C. D. Salyer, +7

Journal of Medicinal Chemistry

Innate Immune SystemImmunologyImmune RegulationPharmacotherapyImmunotherapeutics +25

Structure‐Based Design of Novel Human Toll‐like Receptor 8 Agonists

Hari Prasad Kokatla, Diptesh Sil, Hiromi Tanji, +5

ChemMedChem

Perfluorocarbon Nanoemulsions Enhance Therapeutic siRNA Delivery in the Treatment of Pulmonary Fibrosis

Ling Ding, Siyuan Tang, Weimin Tang, +8

Advanced Science

Polycation fluorination improves intraperitoneal siRNA delivery in metastatic pancreatic cancer

Hang Yu, Siyuan Tang, Weimin Tang, +9

Journal of Controlled Release

Polycation FluorinationPancreatic CancerPolymer-drug ConjugateMedicinePathology +4

Intraperitoneal siRNA Nanoparticles for Augmentation of Gemcitabine Efficacy in the Treatment of Pancreatic Cancer

Siyuan Tang, Hang Yu, Ling Ding, +6

Molecular Pharmaceutics

NanoparticlesEngineeringBiomedical EngineeringTumor BiologyNanomedicine +17

Bound To Shock: Protection from Lethal Endotoxemic Shock by a Novel, Nontoxic, Alkylpolyamine Lipopolysaccharide Sequestrant

Diptesh Sil, Anurupa Shrestha, Matthew R. Kimbrell, +11

Antimicrobial Agents and Chemotherapy

Synthesis of a Highly Water-Soluble Derivative of Amphotericin B with Attenuated Proinflammatory Activity

Samusi A. Adediran, Timothy P. Day, Diptesh Sil, +4

Molecular Pharmaceutics

Medicinal ChemistryPharmaceutical ScienceBioorganic ChemistryAntifungal AgentBiochemistry +13