Selective inhibition of NF-κB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

Eijiro Jimi, Kazuhiro Aoki, Hiroaki Saito, +10

Nature Medicine

InflammationSelective InhibitionBone Morphogenic ProteinNf-κb Blocks OsteoclastogenesisImmunology +7

mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR

Daming Gao, Hiroyuki Inuzuka, Meng-Kwang Marcus Tan, +14

Molecular Cell

Own ActivationSignal TransductionSignaling PathwayMtor Inhibitor DeptorScfβtrcp-dependent Degradation +9

Acetylation-Dependent Regulation of Skp2 Function

Hiroyuki Inuzuka, Daming Gao, Lydia W.S. Finley, +15

Cell

Transcriptional RegulationSignal TransductionMolecular RegulationCellular Regulatory MechanismFunctional Regulation +5

The Association of Notch2 and NF-κB Accelerates RANKL-Induced Osteoclastogenesis

Hidefumi Fukushima, Akihiro Nakao, Fujio Okamoto, +6

Molecular and Cellular Biology

Developmental BiologySignal TransductionBone Morphogenic ProteinSignaling PathwayAutophagy +9

The Current and Future Therapies of Bone Regeneration to Repair Bone Defects

Eijiro Jimi, Shizu Hirata, Kenji Osawa, +3

International Journal of Dentistry

Tissue EngineeringEngineeringFuture TherapiesBone RegenerationAdult Stem Cell +19

Tumor Necrosis Factor α Represses Bone Morphogenetic Protein (BMP) Signaling by Interfering with the DNA Binding of Smads through the Activation of NF-κB

Masato Yamazaki, Hidefumi Fukushima, Masashi Shin, +4

Journal of Biological Chemistry

Expression and role of RANKL in periodontal ligament cells during physiological root‐resorption in human deciduous teeth

Hidefumi Fukushima, Hiroshi Kajiya, Keisuke Takada, +2

European Journal Of Oral Sciences

Cdh1 Regulates Osteoblast Function through an APC/C-Independent Modulation of Smurf1

Lixin Wan, Weiguo Zou, Daming Gao, +11

Molecular Cell

SclerostinMolecular PhysiologySignal TransductionBone Morphogenic ProteinCell Signaling +9

Skp2 is a Promising Therapeutic Target in Breast Cancer

Zhiwei Wang, Hidefumi Fukushima, Hiroyuki Inuzuka, +5

Frontiers in Oncology

Breast OncologyMedicineReceptor Tyrosine KinaseCancer GrowthBreast Cancer +9

SCFβ-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2

Shavali Shaik, Carmelo Nucera, Hiroyuki Inuzuka, +14

The Journal of Experimental Medicine