APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

Yuan-Ta Lin, Jinsoo Seo, Fan Gao, +18

Neuron

Cellular Alterations AssociatedNeurodegenerative DiseasesNeurobiology Of DiseaseMolecular NeuroscienceAlzheimer's Disease +12

Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genome

Hugh P. Cam, Tomoyasu Sugiyama, Ee Sin Chen, +3

Nature Genetics

ChromatinChromatin StructureChromatin RemodelingMedicineGenetics +11

APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

Joel Blanchard, Leyla Anne Akay, José Dávila-Velderrain, +25

Nature

OxysterolPhysiologyDegenerative PathologyNeurologyCholesterol Dysregulation +4

RITS acts in cis to promote RNA interference–mediated transcriptional and post-transcriptional silencing

Ken-ichi Noma, Tomoyasu Sugiyama, Hugh P. Cam, +5

Nature Genetics

Transcriptional RegulationGeneticsRits ActsRna BiologyGene Regulation +6

Cell cycle control of centromeric repeat transcription and heterochromatin assembly

Ee Sin Chen, Ke Zhang, Estelle Nicolas, +3

Nature

ChromatinTranscriptional RegulationChromatin StructureCell DivisionChromatin Remodeling +11

SHREC, an Effector Complex for Heterochromatic Transcriptional Silencing

Tomoyasu Sugiyama, Hugh P. Cam, Rie Sugiyama, +4

Cell

ChromatinTranscriptional RegulationNatural SciencesMolecular BiologyGene Regulation +5

A Common Set of Gene Regulatory Networks Links Metabolism and Growth Inhibition

Hugh P. Cam, Egle Balciunaite, Alexandre Blais, +5

Molecular Cell

Metabolic NetworkSignal TransductionGeneticsGrowth InhibitionCellular Regulatory Mechanism +8

A Role for TFIIIC Transcription Factor Complex in Genome Organization

Ken-ichi Noma, Hugh P. Cam, Richard J Maraia, +1

Cell

ChromatinTranscriptional RegulationGenome OrganizationNatural SciencesGenetics +7

RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production

Tomoyasu Sugiyama, Hugh P. Cam, André Verdel, +2

Proceedings of the National Academy of Sciences

GeneticsMolecular BiologySirna GenerationEpigeneticsSelf-enforcing Loop +15

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

Joel Blanchard, Michael Bula, José Dávila-Velderrain, +12

Nature Medicine

Human Blood–brain BarrierBlood–brain BarrierImmunologyHematologyVitro Reveals +8