The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids

Cholsoon Jang, Sheng Hui, Wenyun Lu, +7

Cell Metabolism

NutritionBiosynthesisBiochemistryBiochemical NutritionPhysiology +7

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

Myriam Aouadi, Gregory J. Tesz, Sarah M. Nicoloro, +5

Nature

InflammationCytokineImmunologyChronic InflammationMacrophage Map4k4 +3

A PP2A Regulatory Subunit Regulates C. elegans Insulin/IGF-1 Signaling by Modulating AKT-1 Phosphorylation

Srivatsan Padmanabhan, Arnab Mukhopadhyay, Sri Devi Narasimhan, +3

Cell

Developmental BiologySignal TransductionMolecular PhysiologySignaling PathwayMolecular Regulation +9

Glucan particles for selective delivery of siRNA to phagocytic cells in mice

Gregory J. Tesz, Myriam Aouadi, Matthieu Prot, +13

Biochemical Journal

Serine catabolism generates liver NADPH and supports hepatic lipogenesis

Zhaoyue Zhang, Tara TeSlaa, Xincheng Xu, +6

Nature Metabolism

HepatologyBiochemistryLiver PhysiologyPhysiologyCatabolism +7

Tumor Necrosis Factor α (TNFα) Stimulates Map4k4 Expression through TNFα Receptor 1 Signaling to c-Jun and Activating Transcription Factor 2

Gregory J. Tesz, Adı́lson Guilherme, Kalyani Guntur, +4

Journal of Biological Chemistry

Map4k4 ExpressionImmunologyInsulin SignalingInflammationMetabolic Syndrome +16

Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction

Jemy A. Gutierrez, Wei Liu, Sylvie Perez, +22

Molecular Metabolism

Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose

Kentaro Futatsugi, Aaron Smith, Meihua Tu, +26

Journal of Medicinal Chemistry

Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition

William P. Esler, Gregory J. Tesz, Marc K. Hellerstein, +20

Science Translational Medicine

Tumor Necrosis Factor-α Induces Caspase-mediated Cleavage of Peroxisome Proliferator-activated Receptor γ in Adipocytes

Adı́lson Guilherme, Gregory J. Tesz, Kalyani Guntur, +1

Journal of Biological Chemistry

ApoptosisImmunologyCell DeathCell Death MechanismsInsulin Signaling +17