Arnaud F. Klein

Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy

Charlotte Fugier, Arnaud F. Klein, Caroline Hammer et al. · Nature Medicine · 2011 · 330 citations

Medicine, Genetics, Molecular Biology +11

Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice

Arnaud F. Klein, Miguel A. Varela, Ludovic Arandel et al. · Journal of Clinical Investigation · 2019 · 105 citations · Full text

Pharmacy, Molecular Biology, Pharmacology +17

Large CTG Repeats Trigger p16-Dependent Premature Senescence in Myotonic Dystrophy Type 1 Muscle Precursor Cells

Anne Bigot, Arnaud F. Klein, E. Gasnier et al. · American Journal Of Pathology · 2009 · 104 citations · Full text

Medicine, Genetics, Molecular Biology +14

Immortalized human myotonic dystrophy muscle cell lines to assess therapeutic compounds

Arandel Ludovic, Polay-Espinosa Micaela, M Maslon Magdalena et al. · Disease Models & Mechanisms · 2017 · 100 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Efficient CRISPR/Cas9-mediated editing of trinucleotide repeat expansion in myotonic dystrophy patient-derived iPS and myogenic cells

Sumitava Dastidar, Simon Ardui, Kshitiz Singh et al. · Nucleic Acids Research · 2018 · 94 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17