Samuel P. Simons

Kinetic analysis of estrogen receptor/ligand interactions

Rebecca L. Rich, Lise R. Hoth, Kieran F. Geoghegan et al. · Proceedings of the National Academy of Sciences · 2002 · 228 citations · Full text

Pharmacy, Biochemistry, Endocrinology +17

Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TRβ subtype-selective thyromimetics

Robert L. Dow, Steven R. Schneider, Ernest S. Paight et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 94 citations · Full text

Pharmacy, Endocrinology, Medicinal Chemistry +11

Structural basis for the catalytic mechanism of human phosphodiesterase 9

Shenping Liu, Mahmoud N. Mansour, Keith Dillman et al. · Proceedings of the National Academy of Sciences · 2008 · 70 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

The 2.0 Å crystal structure of the ERα ligand‐binding domain complexed with lasofoxifene

F.F. Vajdos, Lise R. Hoth, Kieran F. Geoghegan et al. · Protein Science · 2007 · 59 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1

John M. Humphrey, Eddie Yang, Christopher W. am Ende et al. · MedChemComm · 2014 · 37 citations

Medicine, Medicinal Chemistry, Pharmacology +10