Concepedia

Michael D. Lowe

MD

Statistics

Publications

4

Citations

268

H-Index

4

Active since

2010

Affiliations

Pfizer (United States)(Current)

Michael D. Lowe is an author at Pfizer (United States) specializing in medicinal chemistry, drug discovery, and pharmacology.

Publications per year

2010–2017

4

Publications

4

Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L. Lee, Catherine M. Ambler, David R. Anderson et al. · Journal of Medicinal Chemistry · 2017 · 145 citations · Full text

, , +17

Discovery of Isoquinolinone Indole Acetic Acids as Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases

Neelu Kaila, Bruce Follows, Louis Leung et al. · Journal of Medicinal Chemistry · 2014 · 54 citations · Full text

, , +13

Discovery of 2-[1-(4-Chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic Acid (PSI-421), a P-Selectin Inhibitor with Improved Pharmacokinetic Properties and Oral Efficacy in Models of Vascular Injury

Adrian Huang, Alessandro Moretto, Kristin Janz et al. · Journal of Medicinal Chemistry · 2010 · 40 citations · Full text

, , +17

Diazine Indole Acetic Acids as Potent, Selective, and Orally Bioavailable Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases

Neelu Kaila, Adrian Huang, Alessandro Moretto et al. · Journal of Medicinal Chemistry · 2012 · 29 citations · Full text

, , +11

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