Melanie R. Shakespear

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

Mercedes Monteleone, Amanda C. Stanley, Kaiwen Chen et al. · Cell Reports · 2018 · 305 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Histone Deacetylase 7 Promotes Toll-like Receptor 4-dependent Proinflammatory Gene Expression in Macrophages

Melanie R. Shakespear, Daniel M. Hohenhaus, Greg Kelly et al. · Journal of Biological Chemistry · 2013 · 97 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2

Kaustav Das Gupta, Melanie R. Shakespear, James E. B. Curson et al. · Cell Reports · 2020 · 93 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1–Independent Mechanism

Dominik Stammler, Tatjana Eigenbrod, Sarah Menz et al. · The Journal of Immunology · 2015 · 42 citations

Life Sciences, Immunology, Pharmacology +17

HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages

Kaustav Das Gupta, Divya Ramnath, Jessica B. von Pein et al. · Proceedings of the National Academy of Sciences · 2023 · 23 citations · Full text

Life Sciences, Immunology, Molecular Biology +17