Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice

Michael T. Heneka, Magdalena Sastre, Lucia Dumitrescu‐Ozimek, +7

Brain

Acute TreatmentImmune RegulationImmunologyNeurochemical BiomarkersPharmacotherapy +20

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

René Etcheberrigaray, Mathew Tan, Ilse Dewachter, +9

Proceedings of the National Academy of Sciences

Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I] Transgenic Mice

Ilse Dewachter, Delphine Reversé, Nathalie Caluwaerts, +11

Journal of Neuroscience

Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons

Jo Van Dorpe, Liesbet Smeijers, Ilse Dewachter, +14

American Journal Of Pathology

London MutantNeurodegenerative DiseasesAlzheimer's DiseaseMedicineNeurochemical Biomarkers +8

Lower than expected desmosomal gene mutation prevalence in endurance athletes with complex ventricular arrhythmias of right ventricular origin

André La Gerche, Caroline Robberecht, Cuno Kuipéri, +5

Heart

Mutant Presenilins Disturb Neuronal Calcium Homeostasis in the Brain of Transgenic Mice, Decreasing the Threshold for Excitotoxicity and Facilitating Long-term Potentiation

Ilka Schneider, Delphine Reversé, Ilse Dewachter, +10

Journal of Biological Chemistry

Aging Increased Amyloid Peptide and Caused Amyloid Plaques in Brain of Old APP/V717I Transgenic Mice by a Different Mechanism than Mutant Presenilin1

Ilse Dewachter, Jo Van Dorpe, Liesbet Smeijers, +8

Journal of Neuroscience

Amyloid Peptides Abeta40London MutantAmyloid PeptideAlzheimer's DiseaseAging +12

Novel pore mutation in SCN5A manifests as a spectrum of phenotypes ranging from atrial flutter, conduction disease, and Brugada syndrome to sudden cardiac death

Tom Rossenbacker, Sheila J. Carroll, Huajun Liu, +6

Heart Rhythm

Scn5a ManifestsCardiac MuscleCardiomyopathyAtrial FlutterNovel Pore Mutation +7

Aggressive behaviour in transgenic mice expressing APP is alleviated by serotonergic drugs

Dieder Moechars, Martine Gilis, Cuno Kuipéri, +2

Neuroreport

Unconventional intronic splice site mutation in SCN5A associates with cardiac sodium channelopathy

Tom Rossenbacker, Els Schollen, Cuno Kuipéri, +6

Journal of Medical Genetics