Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

Simone Wahl, Alexander Drong, Benjamin Lehne, +103

Nature

ObesityMetabolic SyndromeBody CompositionMetabolic DisorderBody Mass Index +8

Obesity accelerates epigenetic aging of human liver

Steve Horvath, Wiebke Erhart, Mario Brosch, +14

Proceedings of the National Academy of Sciences

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis

Stephan Buch, Felix Stickel, Eric Trépo, +44

Nature Genetics

Genome-wide Association StudyHepatologyMedicineLiver PhysiologyGenetics +8

DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery

M Ahrens, Ole Ammerpohl, Witigo von Schönfels, +19

Cell Metabolism

Bariatric SurgeryMetabolic DisorderGeneticsPathologyFatty Liver Disease +14

A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease

Stephan Buch, Clemens Schafmayer, Henry Völzke, +23

Nature Genetics

Metabolic SyndromeGenome-wide AssociationHepatologySusceptibility FactorBiliary Tract +11

Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)

Alexander Arlt, Iris Bauer, Clemens Schafmayer, +9

Oncogene

Tumor BiologyOncologyMedicineProteomicsProteasome +10

Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting

Claudia Fritsch, Alexander Herrmann, Michael Nothnagel, +8

Genome Research

Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues From Patients

Andreas Teufel, Timo Itzel, Wiebke Erhart, +17

Gastroenterology

GeneticsPathologyFatty Liver DiseaseLiver TissuesMetabolic Syndrome +14

Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis

Pavel Strnad, Stephan Buch, Karim Hamesch, +57

Gut

Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms

Clemens Schafmayer, Stephan Buch, Christina Lange, +58

Gut