Obesity accelerates epigenetic aging of human liver

Steve Horvath, Wiebke Erhart, Mario Brosch, +14

Proceedings of the National Academy of Sciences

DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery

M Ahrens, Ole Ammerpohl, Witigo von Schönfels, +19

Cell Metabolism

Bariatric SurgeryMetabolic DisorderGeneticsPathologyFatty Liver Disease +14

Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues From Patients

Andreas Teufel, Timo Itzel, Wiebke Erhart, +17

Gastroenterology

GeneticsPathologyFatty Liver DiseaseLiver TissuesMetabolic Syndrome +14

Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus

Oliver von Kampen, Stephan Buch, Michael Nothnagel, +39

Hepatology

Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis

Felix Stickel, Stephan Buch, Heinz Zoller, +33

Human Molecular Genetics

“Reversible gastric banding” in surgical treatment of morbid obesity — results of animal experiments

G. Szinicz, Ludwig Müller, Wiebke Erhart, +3

Research in Experimental Medicine

ObesityAnimal ExperimentsBariatric SurgerySurgical TreatmentPhysiology +8

Metabolomic tissue signature in human non‐alcoholic fatty liver disease identifies protective candidate metabolites

Witigo von Schönfels, Eleonora Patsenker, René Fahrner, +18

Liver International

A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease

Helgi B. Schiöth, Adrian E. Desai Boström, Susan K. Murphy, +4

BMC Genomics

TRAIL/NF-κB/CX3CL1 Mediated Onco-Immuno Crosstalk Leading to TRAIL Resistance of Pancreatic Cancer Cell Lines

Claudia Geismann, Wiebke Erhart, Frauke Grohmann, +4

International Journal of Molecular Sciences

ImmunologyImmune RegulationCell DeathPathologyTrail Resistance +18

NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition

Jessica Mwinyi, Adrian E. Desai Boström, Claudia Pisanu, +6

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

BiochemistryNatural SciencesGeneticsMethylation ShiftsLipoprotein Particle Composition +7