Robin M. Gierse

Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy- <scp>d</scp> -xylulose-5-phosphate synthase

Ravindra P. Jumde, Melissa Guardigni, Robin M. Gierse et al. · Chemical Science · 2021 · 33 citations · Full text

First crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

Robin M. Gierse, Rick Oerlemans, Eswar R. Reddem et al. · Scientific Reports · 2022 · 19 citations · Full text

Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening

Di Zhu, Sandra Johannsen, Tiziana Masini et al. · Chemical Science · 2022 · 17 citations · Full text

Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties

Robin M. Gierse, Eswar R. Reddem, Alaa Alhayek et al. · Biochemical and Biophysical Research Communications · 2021 · 16 citations · Full text

Medicinal Chemistry, Biosynthesis, Cellular Enzymology +14

Not Every Hit‐Identification Technique Works on 1‐Deoxy‐<scp>d</scp>‐Xylulose 5‐Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign

Sandra Johannsen, Robin M. Gierse, Aleksandra Olshanova et al. · ChemMedChem · 2023 · 16 citations · Full text