Hideki Hara

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

Stephanie A. Conos, Kaiwen Chen, Dominic De Nardo et al. · Proceedings of the National Academy of Sciences · 2017 · 466 citations · Full text

Apoptosis, Immunology, Immune Regulation +26

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

Hideki Hara, K. Tsuchiya, Ikuo Kawamura et al. · Nature Immunology · 2013 · 363 citations · Full text

Adaptor Asc, Signal Transduction, Signaling Pathway +9

The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection

Hideki Hara, Sergey S. Seregin, Dahai Yang et al. · Cell · 2018 · 282 citations · Full text

Inflammation, Pathogenesis, Immunology +6

Cutting Edge: Nitric Oxide Inhibits the NLRP3 Inflammasome

Eduardo Hernández-Cuellar, K. Tsuchiya, Hideki Hara et al. · The Journal of Immunology · 2012 · 177 citations

Critical Roles of ASC Inflammasomes in Caspase-1 Activation and Host Innate Resistance to <i>Streptococcus pneumoniae</i> Infection

Rendong Fang, K. Tsuchiya, Ikuo Kawamura et al. · The Journal of Immunology · 2011 · 160 citations · Full text