Staphylococcus epidermidis protease EcpA can be a deleterious component of the skin microbiome in atopic dermatitis

Laura Cau, Michael R. Williams, Anna M. Butcher, +8

Journal of Allergy and Clinical Immunology

Protease EcpaAtopic DermatitisPathogenesisContact DermatitisMicrobiology +7

Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

F. Buket Basmanav, Laura Cau, Aylar Tafazzoli, +33

The American Journal of Human Genetics

Developmental BiologyMendelian DisorderGenetic DisorderGeneticsGenetic Mechanism +6

Commensal <i>Cutibacterium acnes</i> induce epidermal lipid synthesis important for skin barrier function

Samia Almoughrabie, Laura Cau, Kellen Cavagnero, +9

Science Advances

Interplay of Staphylococcal and Host Proteases Promotes Skin Barrier Disruption in Netherton Syndrome

Michael R. Williams, Laura Cau, Yichen Wang, +10

Cell Reports

Short chain fatty acids produced by Cutibacterium acnes inhibit biofilm formation by Staphylococcus epidermidis

Kouki Nakamura, Alan M. O’Neill, Michael R. Williams, +4

Scientific Reports

BiofilmsAntimicrobial SusceptibilityBiofilm FormationAntibioticsHealth Sciences +12

In a three-dimensional reconstructed human epidermis filaggrin-2 is essential for proper cornification

Valérie Pendaries, Marina Le Lamer, Laura Cau, +5

Cell Death and Disease

Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown

Laura Cau, Valérie Pendaries, Émeline Lhuillier, +5

Journal of Dermatological Science

Autoimmune DiseaseMedicineCutaneous BiologyPathogenesisPhysiology +6

Peptidylarginine Deiminase Inhibitor Cl-Amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in Reconstructed Human Epidermis

Laura Cau, Hidenari Takahara, Paul R. Thompson, +3

Journal of Investigative Dermatology

Skin DevelopmentCell AutophagySignal TransductionReconstructed Human EpidermisAutophagy +6

Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis

Marie‐Claire Méchin, Laura Cau, M. Galliano, +8

Journal of Dermatological Science

AllergyCutaneous BiologyPeptidylarginine DeiminasesFilaggrin DeiminationUpper Epidermis +6