The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome

Alex Kuo, Jikui Song, Peggie Cheung, +5

Nature

ChromatinGenome InstabilityChromosome DynamicsTranscriptional RegulationChromatin Structure +11

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

Lieselotte Vande Walle, Irma B. Stowe, Pavel Šácha, +15

PLoS Biology

ImmunologyCell DeathInflammationDrug Discovery EffortsPhotoaffinity Labeling +14

Heterobifunctional Molecules Induce Dephosphorylation of Kinases–A Proof of Concept Study

Sayumi Yamazoe, Jeffrey Tom, Yue Fu, +8

Journal of Medicinal Chemistry

Heterobifunctional MoleculesMolecular BiologyConcept StudyChemical BiologySignaling Pathway +15

Sequential Gene Silencing Using Wavelength‐Selective Caged Morpholino Oligonucleotides

Sayumi Yamazoe, Qingyang Liu, Lindsey E. McQuade, +2

Angewandte Chemie International Edition

EngineeringMolecular BiologyReverse-genetic Chemical ProbesGene DeliveryOptogenetics +14

Cyclic Caged Morpholinos: Conformationally Gated Probes of Embryonic Gene Function

Sayumi Yamazoe, Ilya Shestopalov, Elayne Provost, +2

Angewandte Chemie International Edition

Identifying transcriptional programs underlying cancer drug response with TraCe-seq

Matthew T. Chang, Thi Thu Thao Nguyen, Steven T. Staben, +11

Nature Biotechnology

EngineeringMedicineCancer GenomicsPathway AnalysisSystems Biology +5

A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth

Sayumi Yamazoe, Hiroki Shimogawa, Shin‐ichi Sato, +2

Chemistry & Biology

Developmental BiologyCell AdhesionDumbbell-shaped Small MoleculeCell MigrationCell Motility +7

Universal Affinity Capture Liquid Chromatography-Mass Spectrometry Assay for Evaluation of Biotransformation of Site-Specific Antibody Drug Conjugates in Preclinical Studies

Srikanth Kotapati, David Passmore, Sayumi Yamazoe, +12

Analytical Chemistry

Immunocytochemical TechniqueEngineeringImmunologyPayload MetabolismNanomedicine +19

Post-transcriptional mechanisms contribute to Etv2 repression during vascular development

John C. Moore, Sarah Sheppard-Tindell, Ilya Shestopalov, +3

Developmental Biology

Transcriptional RegulationDevelopmental BiologyAngiogenesisNatural SciencesVascular Adaptation +6

Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase

Jennifer H. Gutzman, Ellie Graeden, Isabel Brachmann, +3

Biology Open