Sorcha O’Byrne

Blood and immune development in human fetal bone marrow and Down syndrome

Laura Jardine, Simone Webb, Issac Goh et al. · Nature · 2021 · 159 citations · Full text

Life Sciences, Developmental Biology, Genetics +16

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Jon Kerry, Laura Godfrey, Emmanouela Repapi et al. · Cell Reports · 2017 · 94 citations · Full text

Medicine, Cancer Biology, Molecular Biology +14

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

Sorcha O’Byrne, Natalina Elliott, Siobhan Rice et al. · Blood · 2019 · 94 citations · Full text

Life Sciences, Biology, Developmental Biology +12

Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development

Anindita Roy, Guanlin Wang, Deena Iskander et al. · Cell Reports · 2021 · 88 citations · Full text

Life Sciences, Developmental Biology, Hematology +17

H3K79me2/3 controls enhancer–promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells

Laura Godfrey, Nicholas T. Crump, Sorcha O’Byrne et al. · Leukemia · 2020 · 67 citations · Full text

Medicine, Molecular Biology, Oncology +17