Sorcha O’Byrne

Blood and immune development in human fetal bone marrow and Down syndrome

Laura Jardine, Simone Webb, Issac Goh et al. · Nature · 2021 · 145 citations · Full text

Down Syndrome, Developmental Biology, Autoimmune Disease +12

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

Sorcha O’Byrne, Natalina Elliott, Siobhan Rice et al. · Blood · 2019 · 92 citations · Full text

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Jon Kerry, Laura Godfrey, Emmanouela Repapi et al. · Cell Reports · 2017 · 91 citations · Full text

Tumor Biology, Transcriptional Regulation, Cell Regulation +10

Transitions in lineage specification and gene regulatory networks in hematopoietic stem/progenitor cells over human development

Anindita Roy, Guanlin Wang, Deena Iskander et al. · Cell Reports · 2021 · 87 citations · Full text

H3K79me2/3 controls enhancer–promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells

Laura Godfrey, Nicholas T. Crump, Sorcha O’Byrne et al. · Leukemia · 2020 · 63 citations · Full text