Nicholas T. Crump

Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

Erin M. Bowers, Gai Yan, Chandrani Mukherjee et al. · Chemistry & Biology · 2010 · 641 citations · Full text

P300/cbp Histone Acetyltransferase, Medicinal Chemistry, Drug Target +8

Defining genome architecture at base-pair resolution

Hua Peng, Mohsin Badat, Lars L. P. Hanssen et al. · Nature · 2021 · 188 citations

Sequence Assembly, Functional Genomics, Genetics +7

DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation

Laura Godfrey, Nicholas T. Crump, Ross Thorne et al. · Nature Communications · 2019 · 163 citations · Full text

BET inhibition disrupts transcription but retains enhancer-promoter contact

Nicholas T. Crump, Erica Ballabio, Laura Godfrey et al. · Nature Communications · 2021 · 123 citations · Full text

Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP

Nicholas T. Crump, Catherine A. Hazzalin, Erin M. Bowers et al. · Proceedings of the National Academy of Sciences · 2011 · 110 citations · Full text

Histone Modifications, Histone H3, Epigenetic Change +17