A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

Daniela S. Thommen, Viktor H. Koelzer, Petra Herzig, +16

Nature Medicine

Cancer ImmunosurveillanceNon-small-cell Lung CancerPd-1 BlockadeMedicineImmunology +6

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

Christopher Garris, Sean P. Arlauckas, Rainer H. Köhler, +20

Immunity

Cancer ImmunosurveillanceImmunologyTumor ImmunityImmune RegulationImmune Surveillance +10

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

Haiping Wang, Fabien Franco, Yao-Chen Tsui, +17

Nature Immunology

Cancer ImmunosurveillanceMedicineT-regulatory CellImmunologyImmunoediting +8

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells

Michal A. Stanczak, Shoib Sarwar Siddiqui, Marcel P. Trefny, +19

Journal of Clinical Investigation

Radiation OncologyCancer ImmunosurveillanceT CellsNormal T CellsT-regulatory Cell +12

Magnesium sensing via LFA-1 regulates CD8+ T cell effector function

Jonas Lötscher, Adrià-Arnau Martí i Líndez, Nicole Kirchhammer, +28

Cell

InflammationSignal TransductionMolecular PhysiologyT-regulatory CellImmunology +6

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade

Michal A. Stanczak, Natália Rodrigues Mantuano, Nicole Kirchhammer, +21

Science Translational Medicine

Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses

Felix Bayerl, Philippa Meiser, Sainitin Donakonda, +24

Immunity

PD-1+ natural killer cells in human non-small cell lung cancer can be activated by PD-1/PD-L1 blockade

Marcel P. Trefny, Monika Kaiser, Michal A. Stanczak, +7

Cancer Immunology Immunotherapy

Pd-1/pd-l1 BlockadeCancer ImmunosurveillanceImmunologyImmune Checkpoint InhibitorBronchial Neoplasm +6

Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy

Marcel P. Trefny, Nicole Kirchhammer, Priska Auf der Maur, +24

Nature Communications

NK cells with tissue-resident traits shape response to immunotherapy by inducing adaptive antitumor immunity

Nicole Kirchhammer, Marcel P. Trefny, Marina Natoli, +18

Science Translational Medicine