Selective functional inhibition of JAK‐3 is sufficient for efficacy in collagen‐induced arthritis in mice

Tsung H. Lin, Martin Hegen, Elizabeth Quadros, +26

Arthritis & Rheumatism

Jak‐3 SelectivityImmunologyCell ProliferationWhole BloodMusculoskeletal Research +20

IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys

Andrea G. Bree, Franklin Schlerman, Michael Wadanoli, +14

Journal of Allergy and Clinical Immunology

InflammationCytokineAnti-inflammatoryInflammatory Lung DiseaseCynomolgus Monkeys +6

Triad of polar residues implicated in pH specificity of acidic mammalian chitinase

Andrea Olland, James C. Strand, Eleonora Presman, +12

Protein Science

Polar ResiduesProtein AssemblyMolecular BiologyChemical BiologyEnzymatic Modification +14

Kinetic Characterization of Recombinant Human Acidic Mammalian Chitinase

Yi-Te Chou, Shihua Yao, Robert Czerwiński, +11

Biochemistry

A fluorescent assay suitable for inhibitor screening and vanin tissue quantification

Benfang Helen Ruan, Derek C. Cole, Paul W. Wu, +11

Analytical Biochemistry

Preclinical Drug EvaluationBiochemistryMedicineVanin Tissue QuantificationBioanalysis +9

Identification of an Orally Efficacious Matrix Metalloprotease 12 Inhibitor for Potential Treatment of Asthma

Wei Li, Jianchang Li, Yuchuan Wu, +17

Journal of Medicinal Chemistry

AsthmaInflammatory Lung DiseaseLung InflammationImmunologyAllergen +14

Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD)

Yuchuan Wu, Jianchang Li, Junjun Wu, +18

Bioorganic & Medicinal Chemistry Letters

PharmacologyPulmonary PharmacologyPharmacotherapyMedicinePulmonary Disease +2

Evolutionary and biochemical differences between human and monkey acidic mammalian chitinases

Rustem Krykbaev, Lori Fitz, Padmalatha S. Reddy, +5

Gene

BiologyGanglion CellBiochemistryNatural SciencesEvolutionary Biology +3

Complementary Combining Site Contact Residue Mutations of the Anti-digoxin Fab 26–10 Permit High Affinity Wild-type Binding

Mary K. Short, Rustem Krykbaev, Philip D. Jeffrey, +1

Journal of Biological Chemistry

Modifying specificity of antidigoxin antibodies using insertional mutagenesis

Rustem Krykbaev, Panayota Tsantili, Philip D. Jeffrey, +1

Protein Science

Bioorganic ChemistryProtein AssemblyImmunologyMolecular BiologyTrp94 Mutation +15