Robert Czerwiński

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

Eli M. Wallace, James P. Rizzi, Guangzhou Han et al. · Cancer Research · 2016 · 329 citations

Medicine, Oncology, Pharmacology +17

Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820

Xinlin Du, Oleg A. Volkov, Robert Czerwiński et al. · Structure · 2019 · 178 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +6

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2<i>S</i>,5<i>R</i>)-5-((7<i>H</i>-Pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans

Atli Thorarensen, Martin E. Dowty, Mary Ellen Banker et al. · Journal of Medicinal Chemistry · 2017 · 165 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Catalytic Domain Crystal Structure of Protein Kinase C-θ (PKCθ)

Zhang‐Bao Xu, Divya Chaudhary, Stéphane Olland et al. · Journal of Biological Chemistry · 2004 · 145 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (<i>S</i>)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1<i>H</i>-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)

Paul M. Wehn, James P. Rizzi, Darryl D. Dixon et al. · Journal of Medicinal Chemistry · 2018 · 114 citations · Full text

Medicine, Medicinal Chemistry, Oncology +15