Parsing the Interferon Transcriptional Network and Its Disease Associations

Sara Mostafavi, Hideyuki Yoshida, Devapregasan Moodley, +17

Cell

Blockade of the interleukin‐21/interleukin‐21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis

Deborah Young, Martin Hegen, Hak Ling Margery, +11

Arthritis & Rheumatism

Characterization of adenosine deaminase binding to human CD26 on T cells and its biologic role in immune response

Runyu Dong, Junichi Kameoka, Martin Hegen, +4

The Journal of Immunology

Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats.

Jaya Krishnan, Vladimir Kirkin, Anja Steffen, +5

PubMed

ImmunologyCell ProliferationVegf ReceptorCancer BiologyTumor Biology +15

Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition

Jean‐Baptiste Telliez, Martin E. Dowty, Lu Wang, +33

ACS Chemical Biology

Jak1 InhibitionImmunologyImmune RegulationInnate ImmunityInflammatory Arthritis +28

The T cell triggering molecule Tp103 is associated with dipeptidyl aminopeptidase IV activity.

Martin Hegen, Gerald Niedobitek, Christophe Klein, +2

The Journal of Immunology

T-regulatory CellImmunologyMolecular BiologyPathologyImmunologic Mechanism +17

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( <i>S</i> )-2,2-Difluorocyclopropyl)((1 <i>R</i> ,5 <i>S</i> )-3-(2-((1-methyl-1 <i>H</i> -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Andrew Fensome, Catherine M. Ambler, Eric P. Arnold, +30

Journal of Medicinal Chemistry

Identification of <i>N</i>-{<i>cis</i>-3-[Methyl(7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases

Michael L. Vazquez, Neelu Kaila, Joseph W. Strohbach, +32

Journal of Medicinal Chemistry

ImmunodeficienciesJanus KinasesImmunologyPharmacotherapyImmunotherapy +20

Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2<i>S</i>,5<i>R</i>)-5-((7<i>H</i>-Pyrrolo[2,3-<i>d</i>]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans

Atli Thorarensen, Martin E. Dowty, Mary Ellen Banker, +24

Journal of Medicinal Chemistry

Specific InhibitorDrug TargetPharmacotherapyChemical BiologyPharmaceutical Chemistry +23

Cytosolic Phospholipase A2α–deficient Mice Are Resistant to Collagen-induced Arthritis

Martin Hegen, Linhong Sun, Naonori Uozumi, +5

The Journal of Experimental Medicine